alexa Epigenetic Programming via DNA Deamination

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Epigenetic Programming via DNA Deamination

Methylation of DNA has evolved across many organisms as an epigenetic marker typically associated with transcriptional repression. As cells develop, their epigenetic profile changes to reflect their differentiated state, with the promoters of genes to be silenced getting methylated, and the promoters of genes whose expression is required losing their methylation. Although a significant amount of insight has been gained in the mechanisms of DNA methylation, those of active DNA demethylation are yet to be determined.

Citation: Kazadi D, Basu U (2011) Epigenetic Programming via DNA Deamination. Human Genet Embryol 1:e102.

 
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