A cross-sectional study was carried out to determine seroprevalence of brucellosis from pigs in Central Ethiopia from October, 2013 to May, 2014. A total of 553 blood samples were collected and sera were tested with Rose Bengal Plate Test (RBPT). Out of 553 sera 25 (4.5%) were positive for Brucella antibodies. The results showed that higher seroprevalence in young (<12 months) (5.9%) and male (8.2%) compared to adult (≥12 months) (3.6%) and female pigs (1.6%). The highest positive rates were obtained from pigs originated from Adama area (13.1%) followed by pigs from Addis Ababa area (8.3%). The study showed statistically significant difference (P<0.05) in seroprevalence between origin and sexes of pigs considered. Our study demonstrated the first report of brucellosis from pigs in Central Ethiopia. Therefore further detailed investigations are needed as brucellosis has significant economic implications in pigs and public health importance.