alexa Investigating a Model for Acute Ischemic Pain in Humans

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Investigating a Model for Acute Ischemic Pain in Humans

Content: Background: The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. We examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia.

Methods: Eleven patients with unilateral peripheral arterial disease (PAD) performed treadmill exercise until intolerable ischemic pain urged them to stop. Blood samples were taken before, immediately after treadmill exercise and after a period of recovery. S100B-serum was detected via Elecsys® S100B Immunoassay and IL-6 levels determined via COBAS® IL6 Elecsys 2010.

Citation: Freiberg FJ, Abahji T, Kreth S, Irnich D, Kuhlencordt PJ, et al.

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