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Surface plasmon resonance (SPR) sensing is one promising label-free technique that has found its way into practical applications, with more than 1000 publications annually and more than 20 companies developing SPR-based biosensors systems in sensitive detectors. SPR requires sophisticated optical instrumentation; this has stimulated research in other sensor types such as complementary metal oxide semiconductor (CMOS) field effect transistors and nanowire electrochemical sensors. A fast, portable, ultrasensitive Young interferometer sensor also has been described. It is expected that fully integrated point of care SPR imaging-based diagnostic systems will be introduced in the next five years.
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