Clinically, therapeutic ultrasound has been used by rehabilitation experts in physical therapy and other fields for more than 60 years . Therapeutic indications have included a wide range of conditions (acute and chronic inflammation, tissue healing and repair, scar management, pain modulation and bone healing). Over the past six decades, high frequency ultrasound in the 1-3.3 MHz (1,000,000 to greater than 3,000,000 cycles per second) range has been primarily used in treating these conditions. However, in the past decade, we have seen the introduction of low frequency ultrasound for the management of nonhealing, recalcitrant wounds. Low frequency ultrasound (LFU) generators (<100,000 and > 20,000 hertz) are used for debridement, bioburden control and to stimulate wound healing through both non-contact and jet-spray modes of delivery.