Women, in their age of 20s and 30s have been found to get frequently affected by SLE. Various experimental studies have revealed that women with SLE get affected in their reproductive system. The ovarian function may get hampered by the cause of autoimmune ovarian disease. The females with SLE have to suffer from various complications if they are in their reproductive age. Firstly, the ovarian reserve is reduced leading to reproductive abnormalities. After then, when individuals are treated with chemotherapy agents then, the toxicity of the compounds may lead to infertility. Ultimately, these abnormalities may lead to fetal loss and adverse effect on ovulation procedure. Hence, these patients should follow several recommendations, if they want to preserve their fertility. If the SLE disease is in moderate condition, the, the patients must refer to the reproductive endocrinologist for their fertility preservation options. The pregnant woman should go for regular check up including blood pressure, renal function, blood content, etc. The use of toxic chemical agents should be avoided to reduce the SLE associated complications.