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The covalent lipid modifications on proteins are an important aspect of its functional regulation. The acylation by long fatty acid chain on amino acid residues in proteins alters biochemical characteristic of proteins, that is, conjugation of hydrophobic group heighten its affinity to the lipid membrane structures such as organelles or plasma membrane . The lipid modified proteins targeting to plasma membrane appears their functions by interacting to other proteins nearly located the membrane. For example, recruiting of proteins involving specific intracellular signaling on cell membrane is often achieved by lipid modifications, and the effect enables rapid and effective signal transduction depending on the external environment. Due to this function, the cells finally achieve their proper cellular functions.
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