Prochlorperazine maleate [2-chloro-10-[3-(4-methyl-1- piperazinyl) propyl]-10H-phenothiazine (Z)-2- butenedioate (1:2)] is a phenothiazine derivative used as an anti-emetic. It has a prominent antiemetic activity and is most often used for the (short-time) treatment of nausea, vomiting and vertigo. A recent research about emergency department treatment of migraine headache indicated that prochlorperazine was statistically superior to octreotide in clinical success rate and pain relief in migraine patients.
Venkatesh DN, Sankar S, Meyyanathan SN, Muralidharan S, Shanmugam R,et al. (2009) Bioavailability Studies on Developed ProchlorperazineMaleate Sustained Release Tablets by HPLC. J Bioanal Biomed 1: 054-057. doi: 10.4172/1948-593X.1000012