A saliva sample was collected before and after 5 mg of prednisolone was administered at 10 PM. Of the 34 PTSD+ patients, 19 had MDD comorbidity (PTSD+MDD). The cortisol curve of PTSD+MDD patients was similar to that of controls, and both were higher than that of PTSD patients. Cortisol levels after awakening after prednisolone administration were negatively correlated with the CAPS, BAI, and sexual abuse score on the ETI.
Citation: Mello MF (2013) The Effect of Comorbid Depression and Sexual Abuse during Childhood on Glucocorticoid and Mineralocorticoid Receptor Sensitivity of Patients with Post-Traumatic Stress Disorder. J Depress Anxiety S4:004.