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Gastro-esophageal-reflux disease (GERD) and its complication, Barrett's esophagus, are highly prevalent and request medical attention all over the world. Proton pump inhibitors (PPI) are the treatment of choice, acting as gastric acid secretion inhibitors. The transient increase in blood pH following gastric secretion has been termed alkaline tide (AT) phenomenon, and its measurement provides a non-invasive and inexpensive test for evaluation of hypo- and hyper secretory states. Till today it has never been shown that PPI is able to prevent AT, and to optimize treatment for GERD.
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