Dyslipidemia is a pathological condition in which lipid levels are deranged. It is a major health problem leading to dreadful complications such as Waja‘al-Qalb (angina pectoris), Khafaqan (palpitation) Iflas al Qalb (myocardial infarction), Siman-e-Mufrit (obesity), Ziabetus Shakri (diabetes), Sartan (cancer) and abrupt death etc. Overall prevalence of metabolic syndrome which includes dyslipidemia in south Asians varies from 20% to 32% and 11% to 41% among Indians which pose great challenge on the economic implications and health care burden on the society. Many synthetic anti-dyslipidemia drugs like statins, fibrates, cholesterol absorption inhibitors, nicotinic acid are the corner stone of management at present, but these drugs are loaded with adverse effects and prolong use remains an impediment. In view of this, a recent trend has been developed and scientists are turning their attention towards the alternative medicine to overcome such dreaded ailments. In Unani Medicine many drugs have been used for the treatment of Siman-e-mufrit (obesity) which closely resembles to dyslipidemia in several aspects and many of these drugs have already been reported for their anti-dyslipidemia and other activities, among a huge list of such drugs a few have been reviewed in this paper.