The treatments of bone loss have been extended to the molecular level and previous research has found that vascular endothelia growth factor (VEGF) can enhance the vascular network building around bone injury to aid healing progress. In this manuscript, we discussed the effects of VEGF on bone cells metabolism and activity. VEGF could enhance osteogenesis by inducing neovascularization and direct effects on bone cells via regulation on genes osteoprotegerin (OPG)/the receptor activator of nuclear factor kappa beta ligand (RANKL), alkaline phosphatase (ALP), osteopontin (OPN) and osteocalcin (OCN), without causing abnormal cell metabolism, which may shed lights on new clinical treatments of bone loss.
Yang Y, Chai L, Liao C, Qu JY (2014) Effects of VEGF on Bone Cellsâ Metabolism and Activity. Dentistry 4:247.