alexa Non-neuronal and neuronal BACE1 elevation in the human brain

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Non-neuronal and neuronal BACE1 elevation in the human brain

Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the Aβ deposition in leptomeninge. The cellular origin of angiopathic Aβ and the pathogenic course of CAA remain incompletely understood. The present study attempted to explore these issues by examining changes in β-secretase-1 (BACE1), the obligatory Aβ producing enzyme, relative to Aβ and other cellular markers, in the human cerebrum.

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