alexa Cell - to Species-Level Diversity of Epigenetic Setting for Androgen Receptor Expression in Mammals

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Cell - to Species-Level Diversity of Epigenetic Setting for Androgen Receptor Expression in Mammals

During mammalian development, androgen circulates throughout the body and masculinizes several tissues through endocrinological pathways by binding androgen receptor (AR). At the onset of brain masculinization/defeminization, the androgen-AR system functions in a region-specific manner and, even in adulthood, this system affects the transcription of a certain set of genes. The androgen-AR system, together with several coregulators such as histone modifiers, epigenetically regulates many kinds of genes to express the phenotype of a cell according to the cell’s own androgensensitivity as well as the dose of androgen to which it is exposed. Long-range DNA-protein interactions via chromatin looping structures also set up epigenetic regulatory mechanisms that affect the androgen responsiveness.

 

Citation: Uesaka M, Imamura T (2011) Cell - to Species-Level Diversity of Epigenetic Setting for Androgen Receptor Expression in Mammals. J Steroids Hormon Sci S2:004. doi: 10.4172/2157-7536.S2-004

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