Meta Description: Blood glucose levels are tightly regulated by the opposing actions of insulin signaling and glucagon signaling pathways. During early fasting, glucagon stimulates hepatic glycogenolysis, in which stored glycogen in the liver is broken down into glucose and released into the bloodstream to maintain euglycemia.

Blood glucose levels are tightly regulated by the opposing actions of insulin signaling and glucagon signaling pathways. In the fed and postprandial states, glucose is absorbed in the gastrointestinal tract and enters the blood circulation. The elevation in blood glucose levels triggers the secretion of insulin from pancreatic β cells. This, in turn, stimulates glucose utilization in peripheral tissues such as muscle and adipose tissue, and suppresses hepatic glucose production.

Eventually, blood glucose levels return to the normal defined range due to insulin signaling. In the fasting state, blood glucose levels drop, and glucagon is secreted from α cells of the pancreas. During early fasting, glucagon stimulates hepatic glycogenolysis, in which stored glycogen in the liver is broken down into glucose and released into the bloodstream to maintain euglycemia.

For more details: https://www.omicsonline.org/open-access/antagonistic-effects-of-insulin-signaling-and-glucagon-signaling-on-controlling-hepatic-gluconeogenic-gene-expression-2161-0665.1000200.php?aid=26070

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