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Prospectively assessed the immunological response to the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in autologous cell transplantation (AHCT) recipients using pneumococcal IgG (PNEIGG) titers. PNEIGG titers were collected prior to transplant (titer 1), 3-7 days following AHCT (titer 2), 1 year later at the time of vaccination (titer 3), and at 4-6 wks after vaccination (titer 4) for each of the 23 serotypes included in PPSV23.