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Postmenopausal coronary heart disease (CHD) has become a major cause of morbidity and mortality in women. After the onset of menopause, the risk of CHD in women increases dramatically because of hormone deficiency especially in estrogens.
Decreased ovarian function involved in increased plasma concentrations of total and LDL-cholesterol and in an increased LDL/HDL ratio are among the important risk factors for the development of CHD. Several lines of evidences indicate that estrogens are important regulators of lipid homeostasis.
Estrogen replacement therapy has been shown to play an important beneficial role in the improvement of CHD in postmenopausal women. However, compliance with long-term estrogen replacement therapy for menopausal women is poor because of side effects.
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