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The effect of IVIG in cancer treatment is likely to be mediated by immune cells that regulate tumor progression. Here we studied the effect of IVIG on tumor development in two immunologically contrasting mouse strains, CBA and C57BL/6. We compared the rate of tumor growth, the number of circulating neutrophils and oxidative characteristics of tumor tissue in IVIG-treated and control mice. These results suggest the tight link between the effects of IVIG upon neutrophils and tumor tissue redox balance as a part of regulatory mechanism of tumor growth.
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