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The term molecular recognition refers to the specific interaction between two or more molecules through non-covalent bonding such as hydrogen bonding, hydrophobic forces. Molecular recognition plays an important role in biological systems. It is observed in between receptor-ligand, antigen-antibody, DNA-protein etc. It can be subdivided into static molecular recognition and dynamic molecular recognition. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. The hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable.
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