alexa Proliferation of Myocytes in humans at the end-stage of cardiac failure

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Proliferation of Myocytes in humans at the end-stage of cardiac failure

From decades ago, the dogma persisted that cardiac myocytes are terminally differentiated cells and division of muscle cells is impossible in the adult heart. In recent times, mitotic division of myocytes have been observed, but those observations were challenged on the assumption that the rate of cell proliferation was inconsequential for actual tissue regeneration. However, the analysis of routine histological preparations constituted the basis for the belief that myocytes were unable to re-enter the cell cycle and divide.

http://www.pnas.org/content/95/15/8801.short

 
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