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Histopathology remains the mainstay of confirming the diagnosis of prostate cancer (PCa). Grey scale (B-mode) transrectal ultrasound (TRUS), which is based on increased brightness in relation to the strength of the echo, is widely used for prostate biopsies. The grey scale TRUS is useful in guiding needles into the desired region as per the biopsy protocol however, it does not differentiate between normal and cancerous tissue in up to 50% of the cases.
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