Mesoporous silica materials benefit from unique features that have attracted substantial interest for their use as catalyst-immobilization matrices. These features include high surface area, chemical, thermal, and mechanical stability, highly uniform pore distribution and tunable pore size, high adsorption capacity, and an ordered porous network for free diffusion of substrates and reaction products. Solid supported catalysts are of great interests in both academic and industrial arenas due to their recyclability, enhanced catalytic reactivity, and selectivity. Inorganic, organic end enzymatic catalysis fields have been revolutionized by introduction of mesoporous silica nanomaterials as support due to dramatic increase of contact area and thus contributing to overall reaction yield [1-4]. Furthermore, mesoporous silica offers the opportunity of multifunctionalization and therefore, multiple catalyst immobilizations. The ability to sequester selectively molecules buy their functionality makes mesoporous silica catalyst championing high selectivities. This editorial will highlight the most important achievements in the field of mesoporous silica-supported catalysis.