Hair growth contains four phases: growing anagen (A), regressive catagen (C), resting telogen (T) and latent kenogen, during which the hair follicle remains empty after hair shedding. Alopecia sufferers commonly enter catagen phase prematurely and persist latent phase for a variable duration. Hence, kenogen and particularly the onset of catagen are important parameters for understanding the consequences of changes in the hair growth cycle. Normally, over 80% of the hairs are in their anagen phase and less than 20% in telogen and catagen phase, corresponding to an A/T ratio above 4. Conditions of Androgenetic Alopecia (AGA) cause premature onset of the catagen phase where hair follicle cells, such as matrix cells and cells linking hair to dermal papilla, massively go through apoptosis.
Citation: Takeda A, Sato A, Zhang L, Harti S, Cauwenbergh G, et al. (2013) CG210 Enables Finasteride 1mg Users to Further Improve Hair Pattern: A Randomized, Double-Blind, Placebo-Controlled Pilot Study of a Novel Product. Hair Ther Transplant 3:107. doi: 10.4172/2167-0951.1000107