Gastrodiscoides hominis) has never been reported. A young lady presented to us with bilateral pitting pedal edema of 2 months duration and laboratory evaluation showed microcytic anemia, low total protein and albumin. Endoscopy and colonoscopy revealed multiple motile worms which were retrieved for species identification. Stool examination revealed polyparasites - Fasciola, Gastrodiscoides, Giardia and Entamoeba. She improved with praziquantel, albendazole and metronidazole. Factors favouring the high endemicity are poor hygiene, consumption of undercooked food, the climatic compatibility for the parasites, swine population and usage of fecal manures for farming. A simple use of anti-helminthic or antiprotozoals in areas of high endemicity can prevent poor outcome among these patients.