All wireless sensor hardware operates in point to point and do not allow for networking sensors with real time patient movement monitoring. Some reported works developed non friendly usage and consumed much power to operate. The developed real time pulse oximetry monitoring system has a pair of light emitting diodes (LEDs), One of LED has awave length in red and other one is in infrared region. The light was detected by a photodiode. The LEDs and photodiode was packed in Velcro strip that facing through a patient’s fingertip. The pulse oximetry data was kept and calculated by microcontroller unit. Pulse oximetry data was read every a second and stored on microcontroller. The data from microcontroller unit was sent to base node via ZigBee wireless network and stored on data logging PC.