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A new binary screening or diagnostic test may be combined sequentially with an existing test using either a believe the positive or believe the negative protocol. Interest then lies in estimating the properties of the new combined protocol and in comparing the new protocol with the existing test via sensitivity, specificity, or likelihood ratios that capture the Trade-off between sensitivity and specificity. read more atwww.omicsonline.org/open-access/using-available-information-in-the-assessment-of-diagnostic-pro-tocols-2155-6180.1000217.pdf