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Major Histocompatibility Complex (MHC) genes produce proteins that are crucial in fighting pathogen assault. Researchers characterized genetic variation and detected more than one MHC class II locus in a tailed amphibian. Globally, amphibian populations are in an unprecedented decline, to a considerable extent caused by rapidly spreading infectious diseases, such as the fungal infection Chytridiomycosis. Therefore future conservation strategies for amphibians could benefit from knowledge about species-specific adaptations indicated by MHC variation, say the researchers writing in the journal Molecular Ecology. The Alpine newt is the first European and the third on the global scale, tailed amphibian species in which the MHC has been studied, and the first one in which more than one MHC II locus has been found.
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