alexa Progression of JC Virus to Virulence in the Brain

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Progression of JC Virus to Virulence in the Brain

Progressive multifocal leukoencephalopathy is a neurodegenerative disease caused by demyelination in the brain. The demyelination is due to infection of oligodendroglial cells by polyomavirus JC, a circular DNA virus. The virus resides as an archetype form in uroepithelial cells and bone marrow of more than 70% of adults, in whom it seldom causes overt symptoms.

 

Citation: Johnson EM, Wortman MJ, Lundberg PS, Daniel DC (2015) Orderly Steps in Progression of JC Virus to Virulence in the Brain. Brain Disord Ther S2:003.

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