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Genetic Variants of Store-Operated Channels and Human Diseases

The functional role of Ca2+ influx in non-excitable cells was elusive for many years. In 1986, Prof. Putney [1] firstly proposed the concept of capacitative Ca2+ channels (also called store-operated channel). In his model, agonist-mediated empty of intracellular Ca2+ stores triggers the activation of calcium channels.

Citation: Chang WC (2012) Genetic Variants of Store-Operated Channels and Human Diseases. J Cell Sci Ther 3:e108.

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