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Brain-derived neurotropic factor (BDNF) levels have been implicated in cognitive function and in the regulation of mood disorders, like depression. The aim of this study was to investigate the cognitive deficits of advanced cancer patients with depression and to assess the influence of various clinical factors on depression and cognition. Low BDNF-levels and the presents of depression however, were associated with cognitive impairment for STM and Piaget tasks. The inability to perform the Piaget tasks adequately in this situation, demonstrates substantial difficulties in reasoning.
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