New opportunities for global enterprise collaboration are leading into an Information and Communications Technology (ICT) era of network ubiquity through the development of new cooperative cyber-processes, which will provide the ability to deliver real-time integration capabilities. This move is supported by interconnected clouds computing with the idea of extending interoperable software and hardware environments from a physical to a virtual infrastructure. Whilst the Internet and cloud technology are indispensable for the operation and collaboration of modern enterprises, they remain nevertheless, at the level of cloud-enabled databases and IT software integration. They fall far short of the knowledge that is relevant for collaborative creation and operation. This paper aims to introduce and develop the concept of a Cloud Knowledge-Oriented Collaboration Systems (cKOCS), which combines cloud computing, the knowledge community, self-learning knowledge and rule-based moderator technology for global collaborative networks.