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Purpose: A prospective work to study and evaluate surgical and endoscopic techniques used in management of post cholecystectomy problems. Patients and Methods: In the period from Mars 2000 to October 2009, a random sample of 630 patients (366 females and 264 males) were collected from general surgery department, and gastro-intestinal endoscopy unit, Assuit University hospitals, and managed accordingly using surgery in 143 patients, and endoscopy in 482 patients (plus percutaneous techniques in 25 patients).