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Patients with type 1 diabetes produce little or no insulin due to an autoimmune destruction of the β-cell mass. Several decades ago, it has been demonstrated that diabetic rats could restore normoglycemia after transplantation with isogeneic islets. This observation resulted in whole-pancreas or islet transplantation to treat patients with type 1 diabetes.
Replenishing a Balanced Mixture of Hormone Producing Cells
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