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Endocrine functions change with age. Changes in three systems are intricately linked to skin aging: the hypothalamic-pituitary-gonadal axis, which affects gonadal function; the adrenals, which produce the sex hormone precursor, dehydroepiandrosterone (DHEA); and the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis, which affects GH production and IGF-I release by systemic organs such as the liver.
Gender Differences in Skin Aging and the Changing Profile of the Sex Hormones with Age
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