alexa Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

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Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review

The microdialysis principle was first employed in the early 1960s, when push-pull cannulas [1] and dialysis sacs [2] were implanted into animal tissues, especially into rodent brains, to directly study the tissues’ biochemistry [3]. While these techniques had a number of experimental drawbacks, such as the number of samples per animal or no/limited time resolution, the invention of continuously perfused dialytrodes in 1972 helped to overcome some of these limitations [4]. Further improvement of the dialytrode concept resulted in the invention of the “hollow fiber”, a tubular semi-permeable membrane with a diameter of ~200-300 μm, in 1974

Erd? F (2015) Microdialysis Techniques In Pharmacokinetic and Biomarker Studies Past, Present and Future Directions A Review. Clin Exp Pharmacol 5:180.

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