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Novel drug delivery systems have attracted the interest of many researchers because of some advantages such as targeting the drug to the special tissues, less toxicity, patient compliance and convenience as well as improvement of the drug physicochemical properties and pharmacokinetics. In the recent years, nanoformulations have become a major concept of modern drug delivery due to their increased surface area, and improved dissolution rate of the less water-soluble drugs.There are different technologies applied for preparation of the nanoparticles such as emulsification solvent evaporation, self-assembly, nanoprecipitation, drawing template synthesis , aerosol flow reactor and electrospinning methods .
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