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The quality of education is assumed by their effectiveness of transfer the knowledge and ineffectiveness in classroom teaching which is reflected through students’ academic achievement. In this study the main objective was to evaluate the teaching methods of Biochemistry for medical undergraduates practiced in the newly built medical faculty at University of Rajarata, Sri Lanka. The laboratory practical classes have undergone changes to include problem-based learning, and tutorials have been revised to include student seminars. In addition, panel discussions and direct student-staff interactions have been used as other learning teaching strategies. The primary objective of the present study was to examine the preferred learning methods of medical students and also to find out ways and means of improving lectures at the Faculty of Medicine, University of Rajarata, Sri Lanka.