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Meta Description: The present study clarified the defense mechanism in neonates by measuring superoxide anion (one of reactive oxygen species: ROS) production and phagocytic activity of polymorphonuclear leukocytes caused by live bacterial stimulation in whole blood. In neonatal polymorphonuclear leukocytes, superoxide anion production was significantly diminished when stimulated with an appropriate amount of Escherichia coli.
Bacterial infection is an important cause of death and long-term morbidity in neonates, especially in immature preterm neonates. The present study clarified the defense mechanism in neonates by measuring superoxide anion (one of reactive oxygen species: ROS) production and phagocytic activity of polymorphonuclear leukocytes caused by live bacterial stimulation in whole blood.
In neonatal polymorphonuclear leukocytes, superoxide anion production was significantly diminished when stimulated with an appropriate amount of Escherichia coli (E. coli). There was no significant difference in ROS production with stimulation of Staphylococcus aureus (S. aureus) between adult and neonatal polymorphonuclear leukocytes. Both adult and neonatal polymorphonuclear leukocytes will show equal activity in E. coli phagocytosis.
For more details:
https://www.omicsonline.org/open-access/diminished-ros-production-2161-0665.1000237.php?aid=40436
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