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At present, cancer is one of the major causes of death worldwide. However, the detailed mechanism of carcinogenesis is not clear yet.
More than 80 years ago Nobel Prize laureate Warburg pointed out that in cancerous cell the loss of oxidative capacity of mitochondria and the glycolytic metabolism shift relative to oxidative phosphorylation as O2 could not reach to mitochondria [1]. However, the nature of the primary mechanism leading to generation of Warburg phenomenon has not been elucidated yet.
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