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The present study was conducted using 15 albino rats (150-200 gm) and was divided equally into one control and two experimental groups. First group was control, second group received chronic depression (7 weeks) by immobilization method using rat immobilizer and third group received standard 4 week treatment (using Flouxetine 1mg/kg body wt. orally) following chronic depression. The animals were sacrificed after the experiment, perfused with 10% formaldehyde, brains were dissected and tissue blocks were processed for paraffin embedding. Observations were made between control, experimental and among experimental groups with equal duration of survival on 10 micron thick H & E stained sections. Estimation of neuronal density of CA3 regions was performed using Motic images plus 2.0 Software. Neuronal density was markedly reduced (93.4 cells/cubic mm) after chronic depression, as compared to control (144.5 cells/cubic mm) and after standard treatment it was enhanced to 159.3 cells /cubic mm. Statistical analysis of these results suggested that effect of long-term stress-induced depression on hippocampus may significantly be reversed by the pharmacological intervention with known antidepressants.
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