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A series of 1,3,5-triazines derivatives were designed, synthesized and evaluated their biological activity. The preliminary investigation showed that most compounds displayed good to excellent potency against seven tested cancer cell lines as compared with ZSTK474. Compounds 5a, 7a and 7d were further examined for their inhibitory activity against PI3Kα kinase. The most promising compound 7d (PI3Kα half-maximal inhibitory concentration [IC50] = 10.56 nM) showed remarkable cytotoxicity against H1975, A549, PC9, HCT116, BT549, CNE2 and SW480 cell lines with IC50 values of 2.83 μM, 4.62 μM, 0.29 μM, 3.92 μM, 0.56 μM, 3.53 μM and 1.27 μM, respectively. The structure-activity relationships (SARs) analyses will guide us to further refine the structure of 1,3,5-triazines derivatives to achieve optimum anticancer activity.
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