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63-year-old woman visited her local doctor complaining of acid regurgitation. Esophagogastroduodenoscopy revealed a protruding lesion with a modulated mucosal surface in the gastric antrum, with mucosal biopsies indicating well-differentiated adenocarcinoma. Because of a positive urea breathe test, while the patient was waiting for elective surgery she underwent Helicobacter pylori eradication therapy. Thirty days after eradication therapy, the patient underwent laparoscopic distal gastrectomy with regional lymph node dissection.