alexa The Evolution of Calcium Release Channels: a Story of Expansion and Loss?

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The Evolution of Calcium Release Channels: a Story of Expansion and Loss?

Calcium ions are utilised as a second messenger in all forms of cellular life. In contrast to bacteria and archaea, eukaryotes possess endomembrane systems, exemplified by the endoplasmic reticulum. Such organelles act as intracellular stores in Ca2+ signalling processes, with two distantly related calcium channels, the inositol 1,4,5- trisphosphate receptors and ryanodine receptors, acting as Ca2+ release mechanisms. Despite their fundamental role, the evolutionary origins of such Ca2+ release channels have proven difficult to elucidate. The current study presents updates on the phylogeny of this channel superfamily and analyses of the domain architectures of these proteins.

Citation: Zheng L, Mackrill JJ (2015) The Evolution of Calcium Release Channels: a Story of Expansion and Loss?. J Phylogen Evolution Biol 3:150. doi: 10.4172/2329-9002.1000150

 
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