alexa Escherichia Coli are Susceptible to Thiazolides If the Tolc Efflux System is Inhibited

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Escherichia Coli are Susceptible to Thiazolides If the Tolc Efflux System is Inhibited

 FDA for treatment of persistent diarrhoea caused by Crypto sporidium parvum and Giardia duodenalis in children and adults [1]. Meanwhile, a series of NTZ-derivatives had been synthesized and tested for activity against intracellular protozoans, bacteria, viruses and tumour cells. The respective in vitro, in vivo, and clinical studies have been reviewed elsewhere [2]. Susceptibility of G. duodenal is to thiazolides is dependent on the presence of a nitro group [3]. Therefore, enzyme systems reducing the nitro group to a toxic intermediate or radical have been extensively investigated as potential targets in this parasite [4,5].

Citation: Joachim Müller, Jathana Vaithilingam, Judah Lee Rosner and Norbert Müller (2014) Escherichia Coli are Susceptible to Thiazolides If the Tolc Efflux System is Inhibited. J Develop Drugs 3:124. doi: 10.4172/2329-6631.1000124

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