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FDA for treatment of persistent diarrhoea caused by Crypto sporidium parvum and Giardia duodenalis in children and adults [1]. Meanwhile, a series of NTZ-derivatives had been synthesized and tested for activity against intracellular protozoans, bacteria, viruses and tumour cells. The respective in vitro, in vivo, and clinical studies have been reviewed elsewhere [2]. Susceptibility of G. duodenal is to thiazolides is dependent on the presence of a nitro group [3]. Therefore, enzyme systems reducing the nitro group to a toxic intermediate or radical have been extensively investigated as potential targets in this parasite [4,5].