FDA for treatment of persistent diarrhoea caused by Crypto sporidium parvum and Giardia duodenalis in children and adults . Meanwhile, a series of NTZ-derivatives had been synthesized and tested for activity against intracellular protozoans, bacteria, viruses and tumour cells. The respective in vitro, in vivo, and clinical studies have been reviewed elsewhere . Susceptibility of G. duodenal is to thiazolides is dependent on the presence of a nitro group . Therefore, enzyme systems reducing the nitro group to a toxic intermediate or radical have been extensively investigated as potential targets in this parasite [4,5].
Citation: Joachim Müller, Jathana Vaithilingam, Judah Lee Rosner and Norbert Müller (2014) Escherichia Coli are Susceptible to Thiazolides If the Tolc Efflux System is Inhibited. J Develop Drugs 3:124. doi: 10.4172/2329-6631.1000124