alexa NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model

Neurodegenerative Diseases (NDDs) are becoming rampant in sub- Saharan Africa due to food based toxicity and thus, there is an urgent need to conduct cell based research using cheap and appropriate models [6,7]. Previous studies have examined the etiology and cellular mechanisms involved NDDs such as Konzo, tropical ataxic neuropathy and movement disorders often associated with the loss of adrenergic pigmented neurons in the Substantia Nigra (SN) [8,9]. Available cellular models often demonstrate cell death due to aging and have been achieved through manipulation and mutation of the PD genes [10-12]. Other models involves the use of primates; through chemotoxin induced Parkinsonism that selectively targets the dopaminergic cells of the SN [13,14]. Most in vitro models are nonpigmented and thus cannot demonstrate the role of melanosomes in the selective vulnerability of these cells [15]. Also, the in vivo models cannot be observed directly as direct cellular observation is rather invasive [16,17]. Thus, there is a need for the development of in vitro or ex vivo cell models capable of showing synaptic denervation and the roles of pigment vesicles in the cause, progression and therapeutic targeting of PD.

Citation: Olalekan O, Sanya OJ (2014) NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model and Mechanism in Parkinson's disease. J Biomol Res Ther 3:114.

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords