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Neurodegenerative Diseases (NDDs) are becoming rampant in sub- Saharan Africa due to food based toxicity and thus, there is an urgent need to conduct cell based research using cheap and appropriate models [6,7]. Previous studies have examined the etiology and cellular mechanisms involved NDDs such as Konzo, tropical ataxic neuropathy and movement disorders often associated with the loss of adrenergic pigmented neurons in the Substantia Nigra (SN) [8,9]. Available cellular models often demonstrate cell death due to aging and have been achieved through manipulation and mutation of the PD genes [10-12]. Other models involves the use of primates; through chemotoxin induced Parkinsonism that selectively targets the dopaminergic cells of the SN [13,14]. Most in vitro models are nonpigmented and thus cannot demonstrate the role of melanosomes in the selective vulnerability of these cells [15]. Also, the in vivo models cannot be observed directly as direct cellular observation is rather invasive [16,17]. Thus, there is a need for the development of in vitro or ex vivo cell models capable of showing synaptic denervation and the roles of pigment vesicles in the cause, progression and therapeutic targeting of PD.
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