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The lipid–polymer hybrid NPs (LPNs) combining the positive attributes of both liposomes and polymeric NPs are increasingly being considered as promising candidates to carry therapeutic agents safely and efficiently [9,10]. LPNs are polymeric nanoparticles enveloped by lipid layers [11]. The inclusion of lipid coat enables the hybrid nanoparticles to encapsulate not only water-insoluble drugs, but also water-soluble drugs with greater encapsulation efficiency. LPNs exhibit high structural integrity, stability during storage, and controlled release capability attributed to the polymer core, and high biocompatibility and bioavailability owed to the lipid layer [12,13].
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