A diagnosis of PJI was performed in 27 cases, 22 with a positive radionuclide scan and 5 with a secreting fistula. Frozen sections examination resulted positive in 26 cases. The only case with negative results had positive radionuclide scan and infection was confirmed by positive intraoperative cultures and histopathology (1 false negative frozen section). In 2 cases, both with positive radionuclide and fresh frozen sections, a Girdlestone procedure were performed due to the severity of infection with bone disruption. The other 25 patients performed a two-stage prosthetic joint replacement. Considering the combination of the 2 tests as a single one (radionuclide scan and frozen section), a concordant combination of the two tests had a 100% sensitivity and a 95% specificity, with a 96% correct classification rate (efficiency). The PPV resulted 75% PPV and the NPV 100%. All patients with a diagnosis of PJI (27 cases) were treated with antibiotic for 8 weeks (intravenous for at least 2 weeks).
Citation: Carrega G, Burastero G, Ciolo LD, Causi SL , Riccio G (2013) Role of Nuclear Imaging and Intraoperative Frozen Section in Patients with Late Prosthetic Joint Infections. J Med Diagn Meth 2:124.