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Methylation of DNA has evolved across many organisms as an epigenetic marker typically associated with transcriptional repression. As cells develop, their epigenetic profile changes to reflect their differentiated state, with the promoters of genes to be silenced getting methylated, and the promoters of genes whose expression is required losing their methylation.
Citation: Kazadi D, Basu U (2011) Epigenetic Programming via DNA Deamination. Human Genet Embryol 1:e102
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