alexa Isolation of New Hexapeptides?JBIR-39 and JBIR-40?from a Marine Sponge-Derived Streptomyces sp. Sp080513SC-24

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Isolation of New Hexapeptides?JBIR-39 and JBIR-40?from a Marine Sponge-Derived Streptomyces sp. Sp080513SC-24

Marine microorganisms, particularly marine Actinobacteria, have attracted considerable attention as one of the most important resources for new biologically active metabolites. For example, new compounds have been isolated from Actinobacteria of sponge origin. Our group was recently engaged in the isolation of Actinobacteria from marine sources. Some of the isolated Actinobacteria have been found to produce new compounds, namely, the teleocidin analog JBIR-31, the isoprenoids JBIR-46, JBIR-47, and JBIR-48, the salicylamide derivative JBIR-58, and a terpen JBIR-65. Thus, we isolated a number of phylogenetically diverse Streptomyces including six novel members of the genus Streptomyces from a marine sponge, Haliclona sp., which is inhabited by diverse Actinobacteria, and then comprehensively searched for secondary metabolites in the cultures of isolated strains. We succeeded in isolating 2 new anthracyclines, tetracenoquinocin and 5-iminoaranciamycin, and 2 new tetrapeptides, JBIR-34 and JBIR-35. In this study, we purified 2 new compounds, termed JBIR-39 (1) and JBIR-40 (2) (Figure 1), from the fermentation broth of a new species (Sp080513SC-24) of Streptomyces isolated from Haliclona sp. This paper describes the fermentation, isolation, and structure elucidation of 1 and 2.

 
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