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Obesity is blamed for over 2.8 million annual deaths all over the world with increasing prevalence of related comorbidities, including metabolic (e.g. diabetes mellitus, hyperlipidemia, hypertension) and non-metabolic disorders (e.g., cancer, stroke, depression, polycystic ovary syndrome, fat liver disease, glomerulopathy, bone fragility etc.). Fontaine et al. revealed that a 25-year-old obese patient has a 22% decrease in life expectation.
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